With no resistance and tearful silence, Marlena was booked, fingerprinted and had her "mug shot" taken by Acting Commander In Chief Bo Brady with Evans listed as her last name on the sign held in front of her. With just a moment alone with John before being transported to the county lockup facility, she cried and begged him to help her, declaring she has no memory of any of the killings. Then goes on to question her own innocence and admits she should pay the ultimate price if she is guilty. John kissed and hugged her, professing his undying love and swore that he "will move heaven and earth" to help her. Bo delivered Marlena to county lockup, where she was made to change into the standard orange prison jumpsuit. Assured she would be watched by extra security and also that she was on suicide watch, she entered a holding cell with 6-8 female prisoners who immediately started heckling her. It seemed they all knew the famous Dr. Marlena Evans up close and personal yet she couldn't place any of them. She appeared very fearful and with good reason. One of the females named Crystal had been treated by her and made it very clear Marlena would have trouble. Crystal left, having been notified she had a visitor who turned out to be Nicole. Realizing Jan was more trouble than she was worth, Nicole, decided to take matters into her own hands and promised old porn pal, Crystal, lots of money and legal help to get out of jail and start a new life with her daughter. In turn, Nicole asked Crystal to kill Marlena, who ultimately agreed. Crystal returned to the cell as Nicole left with satisfaction. Back in the cell, things heated up with food being dumped on Marlena by one prisoner and Crystal proudly proclaimed Marlena as hers. A fight broke out and when all was said and done, all the prisoners were unconscious on the floor, scattered about and on top of each other.

Belle begged Shawn not to leave town but things went from bad to worse with a Philip and Shawn escalation confrontation that eventually broke out in FIGHT Number 2 on the show today. With Jan standing at her eavesdropping post, Belle cried about her rights to cry over her Mom's incarceration and the accusations Marlena had been accused of, not to mention that her own life (Belle's) had fallen apart and that Philip was her only friend. The guys were flinging insults and dagger looks at each other which of course had to cross the line. Philip taunted Shawn, then punched him to the ground as Belle tried to separate them.

After the police saw Lucas slap Sami, he was handcuffed, arrested and taken to jail. Kate and Sami had to go also to give statements but once there, there was a lot of thinking being done by everyone. Lucas told the officer Sami's state of mind lately, including her drinking, her inability to cope with her father's death and her mother's arrest, her general out-of-control personality but then stopped just short of completing the sentence, "I love HER!" as Sami looked on. Through flashbacks, she remembered her own near-execution and the poison that was already in her veins, her own mortality virtually over until Lucas had in a last ditch effort burst into the room and admitted his guilt. Sami, bravely told the officer that Lucas was telling the truth and came clean about what had really happened in her apartment. Kate just stood by and wondered to herself what Sami might be up to by her helping Lucas.

As the show ended, Bo received a call from the county lock-up alerting him to the fight in the holding cell. Bo relayed to Hope and John that there had been not just a fight, but also a stabbing and a death. As the show ended, on the jail cell floor, were all the female prisoners but it was not possible to tell what had happened.

On the roof of the Loft, Shawn accused Philip of moving in on Belle, and Philip demanded that Shawn see Belle's side of it. As the two fought, Mimi was accidentally struck. Revived, Mimi brought news about the stabbing incident at Marlena's cell.

At the Holding Cell Marlena appeared beaten up and frightened. She denied accusations that she killed fellow prisoner, Tina. Hope noted that the knife, fashioned from a spoon, could not have been made in the time Marlena was there. Bo questioned the inmates, but not recognizing their answers as lies. The guards claimed Marlena resisted them after threatening prisoners. But Marlena's recollections were of waking up on the floor with bloody hands as a hand swept something from the floor. Using the sharpened spoon, she tried to fend off intimidating prisoners until the guards brutally cuffed her. John suggested, Marlena be tested for any neurological disorder that might affect her behavior. Against Bo's judgment Marlena was sent to be tested by Lexie.

Returning to Sami's apartment, Lucas and Sami began relating to one another warmly. Grateful to Sami for not having him jailed, Lucas apologized for slapping her. But Sami admitted her own poor behavior; disappointed at how she handled situations in the past. While Sami speculated about John's motives for helping Marlena, Lucas could only suggest it was out of love. Surprising Sami, Lucas pledged not to ever sue for sole custody of Will again. Sami asked forgiveness for the many things she'd done to him, while Lucas assured her he didn't hate her. Considering all they'd been through Lucas compared themselves to an old married couple. Promising to be there whenever she needed him, Lucas held Sami as he said, "Will and I need you, too."

Lucas was ready to leave after getting Sami settled for the night, but when she asked him to say the night in bed next to her, Lucas didn't think it a good idea. Admitting that he loved her, Lucas explained, "I'm trying to be the man you deserve, trying to put your needs before my own." With a passionate kiss, Lucas told Sami he loved and wanted her. But he never left once Sami admitted loving him, too.

At University Hospital, Shawn was unable to get through to Belle who was now too distraught over her mother. Hope began to believe in Marlena's guilt, and Bo personally guarded Marlena as Lexie ran tests. Bo assured John that his refusal to testify was not needed since he considered the prison inmates "star witnesses" to a murder. Outside Marlena's room, John watched and whispered, "You're no killer, Doc. I know that in my heart, and now I gotta prove it. I don't know just how I'm going to do that ...but I will.

At the Kiriakis Mansion, Nicole was delighted at television reports of a stabbing in Marlena's Detention Cell. Thinking her plan had worked, she was overheard by Brady whispering to herself. "YES! With Marlena dead, Jan's the only one who can tie me to Victor's murder. Two down, one to go." Thinking she referred to her drink, Brady scolded Nicole for drinking. But Brady grew suspicious at Nicole's apparent disappointment when she learned Marlena was alive.

At University Hospital, Marlena waited for test results, lost the will to live with the options facing her. Having no memory of killing, she was distraught at the damage brought not just to victims' family but her own as well. Belle listened as Marlena asked John to help her die. Bo's grudge strengthened for Marlena and for John who was protecting her. But despite her own grief and conflict, Hope tried to encourage Shawn and John, while suggesting that John come to terms that Marlena could be the Killer.

Mimi advised Philip not to intervene when Shawn followed Belle. Thinking that her Aunt Samantha's poor mental history might be passed on, Belle worried that Shawn's children didn't deserve having a Serial Killer as a grandmother. As she prayed for a sign in the Hospital Chapel, Shawn arrived calling him the answer to her prayer. Philip watched as Shawn embraced Belle saying he would not walk away. Saying he would give Belle the time she needed, Shawn decided not to join the Merchant Marines. Showing her the heirloom Brady ring he was still holding for her, Shawn also replaced the Purity ring to his finger.

At her apartment, Sami abruptly left in a confused state, leaving Lucas calling to find where she'd gone. But she returned just as abruptly with coffee for both of them, saying she'd never really left. Thinking Sami regretted their time together, Lucas apologized for taking advantage of Sami's intoxication. But when he admitted still needing her, Sami returned the sentiment with a kiss. Sami and Lucas were in agreement about Kate's displeasure that they were "together," but in their newfound happiness, didn't seem to care.

At University Hospital, Lexie announced that test results showed no medical reason to explain Marlena's violent behavior. Psychiatric examination showed that Marlena's knowledge of right from wrong might have traumatized her to suppress memories of her deeds. But Lexie told a distressed John, "But she definitely knew exactly what she was doing." But as Bo arranged for Marlena's transport to isolation in prison, John refused to let her go. Head to head in the hospital hall, Bo threatened to arrest John. Before walking away, a desperate John cried, "What do you guys expect from me? This is my wife..."

Mimi's suggestion to use sodium pentothal, a truth serum, on Marlena was agreed upon even by Bo. But at the Kiriakis Mansion, Brady grew suspicious when that news prompted a nervous Nicole to rush to the hospital and stop the procedure. Although Belle admitted to loving him, Shawn found her in Philip's arms when she learned about her mother's test results. And while John argued that a truth serum could railroad Marlena into the gas chamber, Marlena agreed. "I'll take the serum. I have no idea if I have brutally murdered nine of our closest friends. But I really want to know the truth. I want to know what I've done."